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| 1700 |
| | | Boston merchant Samuel Sewall publishes The Selling of Joseph, a very early anti-slavery tract | |
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| 1735 |
| | | John Peter Zenger, editor of the Weekly Journal, is acquitted of libelling the governor of New York on the grounds that what he published was true | |
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| 1754 |
| | | Quaker minister John Woolman publishes the first part of Some Considerations on the Keeping of Negroes, an essay denouncing slavery | |
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| c. 1770 |
| | | The triangular trade, controlled from Liverpool, ships millions of Africans across the Atlantic as slaves | |
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| 1787 |
| | | The Society for the Abolition of the Slave Trade is founded in London, with a strong Quaker influence | |
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| 1787 |
| | | A British ship lands a party of freed slaves as the first modern settlers in Sierra Leone, on the west coast of Africa | |
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| 1789 |
| | | The autobiography of Olaudah Equiano, a slave captured as a child in Africa, becomes a best-seller on both sides of the Atlantic | |
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| 1793 |
| | | The US Congress passes Fugitive Slave Laws, enabling southern slave owners to reclaim escaped slaves in northern states | |
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| 1807 |
| | | Legislation abolishing the slave trade is passed in both Britain and America | |
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| 1808 |
| | | The British government uses Freetown, in Sierra Leone, as a base in the fight against the slave trade | |
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